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Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro

26 May 2021

Abstract excerpt

Telomeres are copied and reassembled each cell division cycle through a multistep process called telomere replication. Most telomeric DNA is duplicated semiconservatively during this process, but replication forks frequently pause or stall at telomeres in yeast, mouse and human cells, potentially causing chronic telomere shortening or loss in a single cell cycle. We have investigated the cause of this effect by...

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Identifiers

PMID: 34048583
DOI: 10.1093/nar/gkab416

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