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The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity

6 Mar 2006

Abstract excerpt

Telomeres, the protein-DNA complexes at the ends of eukaryotic chromosomes, are essential for chromosome stability, and their maintenance is achieved by the specialized reverse transcriptase activity of telomerase or the homologous recombination pathway in most eukaryotes. Here, we identified a human helicase, hPif1 that inhibits telomerase activity. The primary sequence and biochemical analysis suggest that...

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Share to DNA Repair Mechanisms
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PMID: 16522649
DOI: 10.1093/nar/gkl029

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