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Article

Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules

6 Dec 2004

Abstract excerpt

We identified and characterized a human orthologue of Rif1 protein, which in budding yeast interacts in vivo with the major duplex telomeric DNA binding protein Rap1p and negatively regulates telomere length. Depletion of hRif1 by RNA interference in human cancer cells impaired cell growth but had no detectable effect on telomere length, although hRif1 overexpression in S. cerevisiae interfered with telomere...

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Identifiers

PMID: 15583028
DOI: 10.1083/jcb.200408181

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Related research

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Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubulesPMID 15583028Read ↗

The human Rap1 protein complex and modulation of telomere length.Semantic proximity Read ↗

Rap1 affects the length and heterogeneity of human telomeres.Semantic proximity Read ↗

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Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeresSemantic proximity Read ↗

Human RAP1 specifically protects telomeres of senescent cells from DNA damageSemantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast.Semantic proximity Read ↗

Mec1ATR is needed for extensive telomere elongation in response to ethanol in yeast.Semantic proximity Read ↗

Rif1 Regulates the Fate of DNA Entanglements during MitosisSemantic proximity Read ↗

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