Article
Pif1p helicase, a catalytic inhibitor of telomerase in yeast.
Science (New York, N.Y.) - 4 Aug 2000
Zhou J, Monson E K, Teng S C, Schulz V P, Zakian V A
Abstract excerpt
Mutations in the yeast Saccharomyces cerevisiae PIF1 gene, which encodes a 5'-to-3' DNA helicase, cause telomere lengthening and a large increase in the formation rate of new telomeres. Here, we show that Pif1p acts by inhibiting telomerase rather than telomere-telomere recombination, and this inhibition requires the helicase activity of Pif1p. Overexpression of enzymatically active Pif1p causes telomere...
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