Article

Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity

2023-11-06

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation landscape. Although common mutations are well-studied, little research has characterized how the sequence of mutations relates to clinical features. Using published, single-cell DNA sequencing data from three institutions, we compared clonal evolution patterns in AML to patient characteristics, disease phenot...

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Literature Corpus work: b08d1531-7974-50d0-bf81-ca59c2570317
DOI: 10.21203/rs.3.rs-3516536/v1

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