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Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia.

Hematology (Amsterdam, Netherlands) - 1 Dec 2021

Chen Xiao, Zhu Han, Qiao Chun, Zhao Sishu, Liu Lu, Wang Yan, Jin Huimin, Qian Sixuan, Wu Yujie

Abstract excerpt

OBJECTIVES: The study aims to understand geneome diversiﬁcation and complexity that developed in Acute myeloid leukemia (AML). METHODS: Next-generation sequencing (NGS) was used to identify the genetic proﬁles of 22 genes relevant to hematological malignancy in 204 patients with de novo non-M3 AML. RESULTS: At time of initial diagnosis, at least one mutation was identified in 80.9% of patients (165/204). The most...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33491606
DOI: 10.1080/16078454.2020.1858610

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