Article
Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity.
Leukemia - 1 Jul 2024
Schwede Matthew, Jahn Katharina, Kuipers Jack, Miles Linde A, Bowman Robert L, Robinson Troy, Furudate Ken, Uryu Hidetaka, Tanaka Tomoyuki, Sasaki Yuya, Ediriwickrema Asiri, Benard Brooks, Gentles Andrew J, Levine Ross, Beerenwinkel Niko, Takahashi Koichi, Majeti Ravindra
Abstract excerpt
Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation landscape. Although common mutations are well-studied, little research has characterized how the sequence of mutations relates to clinical features. Using published, single-cell DNA sequencing data from three institutions, we compared clonal evolution patterns in AML to patient characteristics, disease phenotype, and outcomes. Mutation...
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