Article
Effect of mutation order on myeloproliferative neoplasms.
The New England journal of medicine - 12 Feb 2015
Ortmann Christina A, Kent David G, Nangalia Jyoti, Silber Yvonne, Wedge David C, Grinfeld Jacob, Baxter E Joanna, Massie Charles E, Papaemmanuil Elli, Menon Suraj, Godfrey Anna L, Dimitropoulou Danai, Guglielmelli Paola, Bellosillo Beatriz, Besses Carles, Döhner Konstanze, Harrison Claire N, Vassiliou George S, Vannucchi Alessandro, Campbell Peter J, Green Anthony R
Abstract excerpt
BACKGROUND: Cancers result from the accumulation of somatic mutations, and their properties are thought to reflect the sum of these mutations. However, little is known about the effect of the order in which mutations are acquired. METHODS: We determined mutation order in patients with myeloproliferative neoplasms by genotyping hematopoietic colonies or by means of next-generation sequencing. Stem cells and...
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