Article

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

2023-05-24

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive malignancy of myeloid progenitor cells characterized by successive acquisition of genetic alterations. This inherent heterogeneity poses challenges in the development of precise and effective therapies. To gain insights into the genetic influence on drug response and optimize treatment selection, we performed targeted sequencing, ex vivo drug screening, and single-cel...

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Literature Corpus work: f0488d2c-19f7-5bf2-a78f-c8be16cc2470
DOI: 10.1101/2023.05.24.541944

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