Article

Soluble Brain Homogenates from Diverse Human and Mouse Sources Preferentially Seed Diffuse Aβ Plaque Pathology When Injected into Newborn Mouse Hosts

2021-11-10

Abstract excerpt

<title>Abstract</title> <p>Background Seeding of pathology related to Alzheimer’s disease (AD) and Lewy body disease (LBD) by the injection of tissue homogenates, purified proteins, or recombinant proteins into model systems has revealed prion-like seeding of the protein aggregates that define these disorders. Most commonly these homogenates are injected into adult mice stereotaxically. Injection of brain lysate...

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Literature Corpus work: b078cb68-77dd-5482-82d3-beb42cb60101
DOI: 10.21203/rs.3.rs-1040944/v1

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Soluble Brain Homogenates from Diverse Human and Mouse Sources Preferentially Seed Diffuse Aβ Plaque Pathology When Injected into Newborn Mouse HostsDOI 10.21203/rs.3.rs-1040944/v1Read

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