Article

Long term worsening of Alzheimer pathology and clinical outcome by a single inoculation of mutated beta-amyloid seeds

2022-12-08

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer’s disease (AD) is characterized by intracerebral accumulation of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These lesions induce synaptic dysfunctions that are strongly correlated with cognitive decline. Intracerebral infusion of well-defined Aβ seeds from synthetic or recombinant non-mutated Aβ<sub>1−40</sub> or Aβ<sub>1−42<...

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Literature Corpus work: 1bc8db3b-ea7b-5714-a677-c58c1d177e4b
DOI: 10.21203/rs.3.rs-2334976/v1

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