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Remodeling Alzheimer-amyloidosis models by seeding

15 Feb 2021

Abstract excerpt

Alzheimer's disease (AD) is among the most prevalent neurodegenerative diseases, with brain pathology defined by extracellular amyloid beta deposits and intracellular tau aggregates. To aid in research efforts to improve understanding of this disease, transgenic murine models have been developed that replicate aspects of AD pathology. Familial AD is associated with mutations in the amyloid precursor protein and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33588898
DOI: 10.1186/s13024-021-00429-4

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