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Article

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

9 Sept 2021

Abstract excerpt

BACKGROUND: The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia. A current area of intense study is the way in which the pathological deposition of these proteins might influence each other, as various combinations of co-pathology between...

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PMID: 34503546
DOI: 10.1186/s13024-021-00486-9

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