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Article

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Nov 2017

Gibbons Garrett S, Banks Rachel A, Kim Bumjin, Xu Hong, Changolkar Lakshmi, Leight Susan N, Riddle Dawn M, Li Chi, Gathagan Ronald J, Brown Hannah J, Zhang Bin, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and related disorders. Pathological tau proteins derived from human AD brains (AD-tau) act as proteopathic seeds that initiate the templated aggregation of soluble tau upon intracerebral injection...

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PMID: 28986461
DOI: 10.1523/JNEUROSCI.2393-17.2017
PMCID: PMC5700428

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