Conversion of Synthetic Aβ to<i>In Vivo</i>Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model

Abstract excerpt

UNLABELLED: The aggregation of amyloid-β peptide (Aβ) in brain is an early event and hallmark of Alzheimer's disease (AD). We combined the advantages of in vitro and in vivo approaches to study cerebral β-amyloidosis by establishing a long-term hippocampal slice culture (HSC) model. While no Aβ deposition was noted in untreated HSCs of postnatal Aβ precursor protein transgenic (APP tg) mice, Aβ deposition emerged...

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