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α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

28 Oct 2023

Abstract excerpt

Abstract Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated that aggregates amplified from LB-αSyn (ampLB) show distinct biological activities in vitro compared to human αSyn preformed fibrils (hPFF) formed de novo. Here we...

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PMID: 37898614
DOI: 10.1038/s41467-023-42705-5

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