Article
Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2014
Eisele Yvonne S, Fritschi Sarah K, Hamaguchi Tsuyoshi, Obermüller Ulrike, Füger Petra, Skodras Angelos, Schäfer Claudia, Odenthal Jörg, Heikenwalder Mathias, Staufenbiel Matthias, Jucker Mathias
Abstract excerpt
Deposition of aggregated amyloid-β (Aβ) peptide in brain is an early event and hallmark pathology of Alzheimer's disease and cerebral Aβ angiopathy. Experimental evidence supports the concept that Aβ multimers can act as seeds and structurally corrupt other Aβ peptides by a self-propagating mechanism. Here we compare the induction of cerebral β-amyloidosis by intraperitoneal applications of Aβ-containing brain...
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