Article
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.
Neurobiology of disease - 1 Jan 2015
Peeraer Eve, Bottelbergs Astrid, Van Kolen Kristof, Stancu Ilie-Cosmin, Vasconcelos Bruno, Mahieu Michel, Duytschaever Hilde, Ver Donck Luc, Torremans An, Sluydts Ellen, Van Acker Nathalie, Kemp John A, Mercken Marc, Brunden Kurt R, Trojanowski John Q, Dewachter Ilse, Lee Virginia M Y, Moechars Diederik
Abstract excerpt
Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau pathology can be transmitted from cell-to-cell; however the mechanisms involved in the initiation of tau fibrillization and spreading of disease linked to progression of tau pathology are poorly understood. We show here that intracerebral...
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