Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

Abstract excerpt

Abstract Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the progression of Alzheimer’s disease. Local overproduction of aggregation-prone Aβ variants could explain the focal initiation of a seeding cascade that subsequently triggers widespread pathology. Several animal models support this seeding concept by demonstrating accelerated Aβ deposition following inoculation with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Cholinesterase and Neurodegenerative Diseases
• Share to Prion Diseases and Protein Misfolding