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Article

Variants in Cas9 and <i>nanos</i> regulatory elements modulate activity and reduce resistance allele formation in homing gene drive

2025-11-05

Abstract excerpt

Gene drive is a novel approach for controlling vector borne disease via either population modification or suppression. Even with high efficiency, though, overall drive performance can be reduced by somatic Cas9 expression and by maternal deposition of Cas9, leading to resistance allele formation. The nanos promoter for Cas9 shows very little leaky somatic expression, but it causes high rates of embryo resistance...

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Literature Corpus work
942aa66f-4e31-5036-97aa-72b54fc8af7f
DOI
10.1101/2025.11.04.686506
Open publication

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Variants in Cas9 and <i>nanos</i> regulatory elements modulate activity and reduce resistance allele formation in homing gene driveDOI 10.1101/2025.11.04.686506
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