Article

New germline Cas9 promoters show improved performance for homing gene drive

2023-07-16

Abstract excerpt

Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR-based homing gene drives, perhaps the most powerful gene drive strategy, convert wild type alleles into drive alleles in heterozygotes with the help of Cas9 and gRNA. However, achieving successful outcomes with these drives often require...

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Literature Corpus work: 21b67282-3bfd-5f28-9a7b-ea01bf8c2c4e
DOI: 10.1101/2023.07.16.549205

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