Article

Regulation of gene drive expression increases invasive potential and mitigates resistance

2018-07-01

Abstract excerpt

CRISPR-Cas9 nuclease-based gene drives rely on inducing chromosomal breaks in the germline that are repaired in ways that lead to a biased inheritance of the drive. Gene drives designed to impair female fertility can suppress populations of the mosquito vector of malaria. However, strong unintended fitness costs, due to ectopic nuclease expression, and high levels of resistant mutations, limited the potential of t...

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Literature Corpus work: 3d699467-97b9-5fc7-aefb-3e24e1ea1b89
DOI: 10.1101/360339

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