Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline Cas9 promoters with improved performance for homing gene drive.

Nature communications - 29 May 2024

Du Jie, Chen Weizhe, Jia Xihua, Xu Xuejiao, Yang Emily, Zhou Ruizhi, Zhang Yuqi, Metzloff Matt, Messer Philipp W, Champer Jackson

Abstract excerpt

Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR-based homing gene drives convert wild type alleles into drive alleles in heterozygotes with Cas9 and gRNA. It is thus desirable to identify Cas9 promoters that yield high drive conversion rates, minimize the formation rate of resistance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to CRISPR-Associated Protein 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Germ Cells

Share to RNA-Binding Proteins

Share to RNA, Guide, CRISPR-Cas Systems

Source

Open in PubMed Open full text

Identifiers

PMID: 38811556
DOI: 10.1038/s41467-024-48874-1
PMCID: PMC11137117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline Cas9 promoters with improved performance for homing gene drive.PMID 38811556Read ↗

New germline Cas9 promoters show improved performance for homing gene driveSemantic proximity Read ↗

Variants in Cas9 and <i>nanos</i> regulatory elements modulate activity and reduce resistance allele formation in homing gene driveSemantic proximity Read ↗

Reducing resistance allele formation in CRISPR gene drive.Semantic proximity Read ↗

Finding the perfect promoter: Correlating single-cell transcriptome data with gene drive performanceSemantic proximity Read ↗

Reducing resistance allele formation in CRISPR gene drivesSemantic proximity Read ↗

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations.Semantic proximity Read ↗

Novel CRISPR/Cas9 gene drive constructs in <i>Drosophila</i> reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populationsSemantic proximity Read ↗

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance allelesSemantic proximity Read ↗

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.Semantic proximity Read ↗

Modelling homing suppression gene drive in haplodiploid organismsSemantic proximity Read ↗

A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.Semantic proximity Read ↗

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.