Article

Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci

2020-02-04

Abstract excerpt

<h4>Background</h4> To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we have created a catalog of genetic variants associated with three stages of transcriptional cis -regulation in primary human coronary artery vascular smooth muscle cells (HCASMC). <h4>Results</h4> To this end, we have...

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Literature Corpus work: b019681a-d0a0-53d8-a773-d69428366291
DOI: 10.1101/2020.02.03.932368

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