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Article

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci.

PLoS genetics - 1 May 2015

Sazonova Olga, Zhao Yuqi, Nürnberg Sylvia, Miller Clint, Pjanic Milos, Castano Victor G, Kim Juyong B, Salfati Elias L, Kundaje Anshul B, Bejerano Gill, Assimes Themistocles, Yang Xia, Quertermous Thomas

Abstract excerpt

To functionally link coronary artery disease (CAD) causal genes identified by genome wide association studies (GWAS), and to investigate the cellular and molecular mechanisms of atherosclerosis, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with the CAD associated transcription factor TCF21 in human coronary artery smooth muscle cells (HCASMC). Analysis of identified TCF21 target genes for...

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Source

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Identifiers

PMID: 26020271
DOI: 10.1371/journal.pgen.1005202
PMCID: PMC4447360

Genes

TCF21
CAD
JUN
JUND

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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