Article

Next-generation cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

2020-02-12

Abstract excerpt

<h4>Abstract/introductory paragraph</h4> Cytosine base editors (CBEs) are molecular machines which enable efficient and programmable reversion of T•A to C•G point mutations in the human genome without induction of DNA double strand breaks 1, 2 . Recently, the foundational cytosine base editor (CBE) ‘BE3’, containing rAPOBEC1, was reported to induce unguided, genomic DNA 3, 4 and cellular RNA 5 cytosine deamina...

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Literature Corpus work: b017b50b-6858-5ee3-b9a6-1ebe8cf306a1
DOI: 10.1101/2020.02.11.944165

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