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Analysis and minimization of cellular RNA editing by DNA adenine base editors

3 May 2019

Abstract excerpt

Adenine base editors (ABEs) enable precise and efficient conversion of target A•T base pairs to G•C base pairs in genomic DNA with a minimum of by-products. While ABEs have been reported to exhibit minimal off-target DNA editing, off-target editing of cellular RNA by ABEs has not been examined in depth. Here, we demonstrate that a current ABE generates low but detectable levels of widespread adenosine-to-inosine...

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PMID: 31086823
DOI: 10.1126/sciadv.aax5717

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