Article

CRISPR adenine and cytosine base editors with reduced RNA off-target activities

2019-05-09

Abstract excerpt

CRISPR-guided DNA base editors enable the efficient installation of targeted single-nucleotide changes. Cytosine or adenine base editors ( CBE s or ABE s), which are fusions of cytidine or adenosine deaminases to CRISPR-Cas nickases, can efficiently induce DNA C-to-T or A-to-G alterations in DNA, respectively 1-4 . We recently demonstrated that both the widely used CBE BE3 (harboring a rat APOBEC1 cytidine deam...

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Literature Corpus work: a035e986-3b06-53c4-8918-e2215c4b6a7a
DOI: 10.1101/631721

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