Improved cytosine base editors generated from TadA variants.

doi:10.1038/s41587-022-01611-9

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Article

Improved cytosine base editors generated from TadA variants.

Nature biotechnology - 1 May 2023

Lam Dieter K, Feliciano Patricia R, Arif Amena, Bohnuud Tanggis, Fernandez Thomas P, Gehrke Jason M, Grayson Phil, Lee Kin D, Ortega Manuel A, Sawyer Courtney, Schwaegerle Noah D, Peraro Leila, Young Lauren, Lee Seung-Joo, Ciaramella Giuseppe, Gaudelli Nicole M

Abstract excerpt

Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR-Cas enzyme, a naturally occurring cytidine deaminase, and an inhibitor of uracil repair. Previous studies have shown that CBEs utilizing naturally occurring cytidine deaminases may cause unguided, genome-wide cytosine deamination. While improved CBEs that decrease stochastic...

Topics

Gene Editing
Cytosine
Mutation
Cytidine Deaminase
Genome
CRISPR-Cas Systems

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Identifiers

PMID: 36624149
DOI: 10.1038/s41587-022-01611-9
PMCID: PMC10188367

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