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Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

28 Apr 2020

Abstract excerpt

Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA. Here we report eight next-generation CBEs (BE4 with either RrA3F [wt, F130L], AmAPOBEC1, SsAPOBEC3B [wt, R54Q], or PpAPOBEC1 [wt, H122A, R33A]) that display...

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CRISPR and Genetic Engineering
Cytomegalovirus and herpesvirus research
RNA regulation and disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32345976
DOI: 10.1038/s41467-020-15887-5

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