Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering of cytosine base editors with DNA damage minimization and editing scope diversification

16 Oct 2023

Abstract excerpt

Cytosine base editors (CBEs), which enable precise C-to-T substitutions, have been restricted by potential safety risks, including DNA off-target edits, RNA off-target edits and additional genotoxicity such as DNA damages induced by double-strand breaks (DSBs). Though DNA and RNA off-target edits have been ameliorated via various strategies, evaluation and minimization of DSB-associated DNA damage risks for most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Cytomegalovirus and herpesvirus research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37843111
DOI: 10.1093/nar/gkad855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering of cytosine base editors with DNA damage minimization and editing scope diversificationPMID 37843111Read ↗

Next-generation cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activitySemantic proximity Read ↗

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activitySemantic proximity Read ↗

High-fidelity base editor with no detectable genome-wide off-target effectsSemantic proximity Read ↗

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors.Semantic proximity Read ↗

Triple base editor catalyzes saturation mutation of adenine, cytidine, and guanine.Semantic proximity Read ↗

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.Semantic proximity Read ↗

Single‐nucleotide editing: From principle, optimization to applicationSemantic proximity Read ↗

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylaseSemantic proximity Read ↗

Improved cytosine base editors generated from TadA variants.Semantic proximity Read ↗

Highly precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusionsSemantic proximity Read ↗

Human cells based directed evolution of adenine base editors with improved efficiencySemantic proximity Read ↗

Analysis and minimization of cellular RNA editing by DNA adenine base editorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.