Article

CD248 activates TGF-β receptor I to promote vascular remodeling in pulmonary arterial hypertension

2026-04-29

Abstract excerpt

I. <h4>ABSTRACT</h4> <h4>Background</h4> Pulmonary arterial hypertension (PAH) is a debilitating cardiopulmonary disease characterized by progressive remodeling of the pulmonary vasculature. Pathologic transforming growth factor-β (TGF-β) signaling is an essential driver of vascular remodeling in PAH. While global inhibitors of TGF-β exist, their clinical application is limited by systemic adverse effects. There...

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Literature Corpus work: afefa376-62d1-566e-8c64-ec6e6e069f20
DOI: 10.64898/2026.04.22.720270

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