Article

Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling

2023-06-05

Abstract excerpt

<h4>Background</h4> Pulmonary arterial hypertension (PAH), a life-limiting condition characterized by dysfunction of pulmonary microvascular endothelium, is predisposed by mutations in several genes that are critical for the proper activation of specific bone morphogenetic protein (BMP) receptor complexes that phosphorylate intracellular Smad1/5/8 in endothelial cells. However, the functional importance of BMP-9 (...

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Literature Corpus work: 04b90c5d-a8ba-5787-9c6a-6d49715f71e1
DOI: 10.1101/2023.06.02.23290910

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