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Liriodendrin Targets PFKFB3 to Suppress Inflammatory Phenotypic Transition and Vascular Remodeling in Pulmonary Hypertension

2026-08-05

Abstract excerpt

<h4>Background</h4> Pulmonary hypertension (PH) involves progressive vascular remodeling and perivascular inflammation. Despite modest clinical improvements with current therapies, their limited ability to reverse remodeling or restore immune homeostasis highlights the need for novel agents. Liriodendrin (Lidd), derived from Sargentodoxae caulis , exhibits anti-inflammatory and antiproliferative activities, but...

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Literature Corpus work
928d8a2e-31ac-58ff-af61-95205dd2f6f6
DOI
10.64898/2026.07.30.741507
Open publication

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