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TXNDC5 Governs Extracellular Matrix Homeostasis in Pulmonary Hypertension

2025-11-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Pulmonary hypertension (PH) is characterized by vascular remodeling without effective treatments. Thioredoxin domain containing 5 (TXNDC5), a member of the protein disulfide isomerases (PDI) family, regulates protein folding and vascular homeostasis, yet its role in PH remains unknown. <h4>METHODS</h4> Label-free proteomics profiled protein expression in lungs from PH patie...

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Literature Corpus work
efcfdb68-c574-520e-b6c5-c06428ee30c6
DOI
10.1101/2025.11.21.689856
Open publication

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TXNDC5 Governs Extracellular Matrix Homeostasis in Pulmonary HypertensionDOI 10.1101/2025.11.21.689856
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