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Epigenetic Activation of Endothelial Smurf1 via EP300-Mediated H3K27ac Disrupts BMPR2 Signaling in Pulmonary Arterial Hypertension

2025-10-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by pulmonary endothelial dysfunction, vascular remodeling, and right ventricular failure. Despite recent advances, the underlying molecular mechanisms remain incompletely understood, and curative treatments are still lacking. Loss of BMPR2 signaling is a hallmark of PAH pathogenesis, yet th...

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Literature Corpus work: f10350a9-965a-56b6-9da5-b6d120034829
DOI: 10.1101/2025.10.30.685664

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