Article

Deletion of Cd248 in <i>Postn</i> positive myofibroblast Fails to Attenuate Cardiac Remodeling and Fibrosis in a Murine Model of Pressure-Overload Cardiomyopathy

2025-09-29

Abstract excerpt

<h4>Background</h4> Cardiac fibrosis, driven by activated Periostin (Postn)-expressing myofibroblasts, is a key pathophysiological feature of heart failure induced by pressure overload. The clinic trial tested tumor vascular regulator CD248 has been validated as a potential anti-fibrotic target in ischemic heart injury. We therefore tested the hypothesis that targeting Cd248 specifically in Postn + myofibroblast...

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Literature Corpus work: 64df9ec1-4260-5a19-9d77-a688ecfdb1bb
DOI: 10.1101/2025.09.26.678917

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