Article
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
American journal of respiratory and critical care medicine - 1 Aug 2021
Tsoyi Konstantin, Liang Xiaoliang, De Rossi Giulia, Ryter Stefan W, Xiong Kevin, Chu Sarah G, Liu Xiaoli, Ith Bonna, Celada Lindsay J, Romero Freddy, Robertson Matthew J, Esposito Anthony J, Poli Sergio, El-Chemaly Souheil, Perrella Mark A, Shi YuanYuan, Whiteford James, Rosas Ivan O
Abstract excerpt
Rationale: CD148/PTRJ (receptor-like protein tyrosine phosphatase η) exerts antifibrotic effects in experimental pulmonary fibrosis via interactions with its ligand syndecan-2; however, the role of CD148 in human pulmonary fibrosis remains incompletely characterized.Objectives: We investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis (IPF).Methods: Conditional...
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