Article

The Interplay Between IL-6, Hepcidin, and BMPR2 Signalling in Pulmonary Arterial Hypertension: Mechanistic Insights into Vascular Remodelling

2025-02-17

Abstract excerpt

<title>Abstract</title> <p>Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary vasoconstriction and vascular remodelling, with mutations in bone morphogenetic protein receptor type 2 (BMPR2) being the most common genetic alteration associated with the disease. While inflammatory mediators like interleukin-6 (IL-6) and the iron-regulatory hormone hepcidin have been implicated in vascular...

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Literature Corpus work: eec84d9f-01f8-59e3-8dab-12aee0b1da61
DOI: 10.21203/rs.3.rs-6024345/v1

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