Article

BMP9 regulates the endothelial secretome to drive pulmonary hypertension

2025-09-04

Abstract excerpt

BMP9, a pleiotropic growth factor cytokine that regulates endothelial function, is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). Loss-of-function mutations in GDF2 are found in heritable PAH, suggesting its function as an endothelial quiescence factor, while agonizing or antagonizing BMP9 signaling are both reported to ameliorate experimental pulmonary hypertension (PH). This study soug...

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Literature Corpus work: 7a79aea7-e5b8-538f-8fba-20bf836b7531
DOI: 10.1101/2025.08.29.673113

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