Article

BMPR-II biomarkers for testing therapeutic efficacy in pulmonary arterial hypertension –the StratosPHere 1 study

2025-12-20

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease where deficiency of the TGF/BMP pathways have causal roles in hereditary and idiopathic forms. It is an attractive candidate for therapeutic intervention but there is an unmet need for clinically-relevant and practical biomarkers that can measure target engagement. A major challenge has been the inaccessibility of lung tissue in disease for mol...

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Literature Corpus work: 6bdc96d6-5f1a-592c-9001-61e017300ac5
DOI: 10.64898/2025.12.19.25342649

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