Article

De novo designed pMHC binders facilitate T cell induced killing of cancer cells

2024-12-03

Abstract excerpt

The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central to adaptive immunity, enabling responses against infections and cancer. The recent approval of TCR-gene-edited T cells for cancer therapy demonstrates the therapeutic advantage of using pMHC recognition to eliminate cancer. However, identification and selection of TCRs from patient material is complex and influence...

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Literature Corpus work: af3240ec-b5fe-508b-b58f-5186a8f0ce78
DOI: 10.1101/2024.11.27.624796

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