Article

Benchmarking generative scaffold design methods for peptide engineering in TCR–MHC complexes

2026-01-23

Abstract excerpt

De novo peptide design at T cell receptor–peptide–major histocompatibility complex (TCR–pMHC) interfaces is a central challenge in computational immunology, with direct implications for vaccine development, cancer immunotherapy, and autoimmune disease. Despite rapid advances in generative protein modeling, there is currently no systematic benchmark evaluating these methods in the highly constrained and immunologic...

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Literature Corpus work: ca1b3863-a1af-59fa-bcac-24e9009ab494
DOI: 10.64898/2026.01.22.701133

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