Article

Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion model

2026-06-14

Abstract excerpt

T cell receptor (TCR)-based immunotherapy holds immense potential for treating cancers, autoimmunity, and infectious diseases, where antigen-specific TCR recognition is crucial for adaptive immune responses. Engineering or de novo generation of the complementarity-determining region 3 (CDR3) loops of TCRs using artificial intelligence offers a powerful alternative to designing antigen-specific TCRs rather than la...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99fa27db-915c-5c36-b8f4-6595a0c12afd
DOI: 10.64898/2026.06.10.730756

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion modelDOI 10.64898/2026.06.10.730756Read

Generative AI-Guided Design of High-Affinity T Cell ReceptorsSemantic proximity Read

T-cell receptor specificity landscape revealed through de novo peptide designSemantic proximity Read

Benchmarking generative scaffold design methods for peptide engineering in TCR–MHC complexesSemantic proximity Read

De novo designed pMHC binders facilitate T cell induced killing of cancer cellsSemantic proximity Read

High-fidelity in silico generation and augmentation of TCR repertoire data using generative adversarial networksSemantic proximity Read

Repertoire-level generation of T-cell epitopes with a large-scale generative transformerSemantic proximity Read

TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-xbinding analysesSemantic proximity Read

Learning Human T Cell Behaviors through Generative AI Embeddings of T Cell ReceptorsSemantic proximity Read

Comprehensive epitope mutational scan database enables accurate T cell receptor cross-reactivity predictionSemantic proximity Read

De novo design of therapeutic scFvs and multi-specific engagers from sequence aloneSemantic proximity Read

Ophiuchus-Ab: A Versatile Generative Foundation Model for Advanced Antibody-Based ImmunotherapySemantic proximity Read

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database.Semantic proximity Read