Article
Targeting peptide antigens using a multiallelic MHC I-binding system.
Nature biotechnology - 1 Oct 2025
Du Haotian, Mallik Leena, Hwang Daniel, Sun Yi, Kaku Chengzi, Hoces Daniel, Sun Shirley M, Ghinnagow Reem, Carro Stephen D, Phan Hoang Anh T, Gupta Sagar, Blackson Wyatt, Lee Hyejin, Choe Christian A, Dersh Devin, Liu Jingjia, Bell Braxton, Yang Hongli, Papadaki Georgia F, Young Michael C, Zhou Emily, El Nesr Gina, Goli Kimia Dasteh, Eisenlohr Laurence C, Minn Andy J, Hernandez-Lopez Rogelio A, Jardine Joseph G, Sgourakis Nikolaos G, Huang Po-Ssu
Abstract excerpt
Identifying highly specific T cell receptors (TCRs) or antibodies against epitopic peptides presented by class I major histocompatibility complex (MHC I) proteins remains a bottleneck in the development of targeted therapeutics. Here, we introduce targeted recognition of antigen-MHC complex reporter for MHC I (TRACeR-I), a generalizable platform for targeting peptides on polymorphic HLA-A*, HLA-B* and HLA-C*...
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