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Article

Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor

13 Feb 2014

Abstract excerpt

T cell receptors (TCRs) are key to antigen-specific immunity and are increasingly being explored as therapeutics, most visibly in cancer immunotherapy. As TCRs typically possess only low-to-moderate affinity for their peptide/MHC (pMHC) ligands, there is a recognized need to develop affinity-enhanced TCR variants. Previous in vitro engineering efforts have yielded remarkable improvements in TCR affinity, yet...

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PMID: 24550723
DOI: 10.1371/journal.pcbi.1003478

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