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Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion

1 Dec 2023

Abstract excerpt

Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy for targeted cancer therapy. We have previously developed a PC-CAR targeting a neuroblastoma-associated PHOX2B peptide, leading to robust tumor cell lysis restricted by two common HLA allotypes. Here, we determine the 2.1-angstrom crystal...

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PMID: 38039376
DOI: 10.1126/sciimmunol.adj5792

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