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Engineering de novo binder CAR-T cell therapies with generative AI

2024-11-25

Abstract excerpt

Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized cancer treatment, with six CAR-T products currently in clinical use 1–4 . Despite their success, high resistance rates due to antigen escape remain a major challenge 5,6 . In silico design of de novo binders (DNBs) has the potential to accelerate the development of new binding domains for CAR-T, possibly enabling personalized therapies for ca...

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Literature Corpus work
4f8ebe6a-e667-546b-a406-9e470ec22e54
DOI
10.1101/2024.11.25.625151
Open publication

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