Article

A generalizable system for antigenic peptide targeting across HLA-I allotypes

2026-05-22

Abstract excerpt

T cell receptors (TCRs) and TCR-mimicking antibodies recognize peptide antigens in the context of specific Human Leucocyte Antigen (HLA-I) allotypes, and the extreme polymorphism of the HLA locus limits the breadth of immunotherapy development. Key barriers include divergent molecular surfaces on HLA proteins and differences in the peptide structure. As a result, existing modalities cannot confer therapeutic cover...

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Literature Corpus work: 465f74b2-54de-5d18-80ce-169a85b20724
DOI: 10.64898/2026.05.21.726655

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