Article

T-cell receptor specificity landscape revealed through de novo peptide design

2025-03-06

Abstract excerpt

T-cells play a key role in adaptive immunity by mounting specific responses against diverse pathogens. An effective binding between T-cell receptors (TCRs) and pathogen-derived peptides presented on Major Histocompatibility Complexes (MHCs) mediate an immune response. However, predicting these interactions remains challenging due to limited functional data on T-cell reactivities. Here, we introduce a computational...

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Literature Corpus work: 10ebd955-8be3-5605-b3df-ae6f98b30a2d
DOI: 10.1101/2025.02.28.640903

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